Take U.S. 17 south through Georgetown. Then take U.S. 521 to S.C. 261 to U.S. 378 to Columbia.
Under certain conditions, a third southbound lane will be formed by reversing flow on the inside northbound lane of U.S. 17 at the Prince George entrance. When this occurs, an additional alternate route from Georgetown will be Black River Road to U.S. 701 to S.C. 51 to S.C. 41 to U.S. 378 at Kingsburg. Instructions will be given to motorists through signs and highway advisory radio.